Scholar: National School of Leadership

Research Articles

Vol. 10 No. 2.0 (2021): Scholar : National School of Leadership

Biological Evaluation of a Novel Potentially Tridentate Schiff Base and its Selected Transition Metal(II) Complexes

Submitted
January 31, 2023
Published
December 31, 2021

Abstract

A Schiff base ligand was synthesized by the condensation of antipyrine-4-carboxaldehyde with 2-amino-3-carboxyethyl-4,5,6,7-tetrahydrobenzo[b]thiophene and its Co(II), Ni(II), Cu(II) and Zn(II) complexes were prepared by microwave assisted solvent free synthesis. The biological activity of the prepared ligand and the metal complexes was assessed by in-vitro testing of their effect on the growth of various strains of bacteria and fungi. A gel electrophoresis assay demonstrated the ability of the complexes to cleave the pUC19 DNA. The alpha amylase inhibitory activity of the ligand and the metal complexes were evaluated and found that metal complexes possess higher activity than the ligand.

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