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Vol. 10 No. 2.0 (2021)
Scholar : National School of Leadership

Research Articles

Biological Evaluation of a Novel Potentially Tridentate Schiff Base and its Selected Transition Metal(II) Complexes

Published 2021-12-31

  • Niecy Elsa Mathews
    • ,
  • Kochukittan Mohanan

Niecy Elsa Mathews
Mar Ivanios College

Kochukittan Mohanan
Mar Ivanios College

Abstract

A Schiff base ligand was synthesized by the condensation of antipyrine-4-carboxaldehyde with 2-amino-3-carboxyethyl-4,5,6,7-tetrahydrobenzo[b]thiophene and its Co(II), Ni(II), Cu(II) and Zn(II) complexes were prepared by microwave assisted solvent free synthesis. The biological activity of the prepared ligand and the metal complexes was assessed by in-vitro testing of their effect on the growth of various strains of bacteria and fungi. A gel electrophoresis assay demonstrated the ability of the complexes to cleave the pUC19 DNA. The alpha amylase inhibitory activity of the ligand and the metal complexes were evaluated and found that metal complexes possess higher activity than the ligand.

Keywords

Schiff Base, Antimicrobial Activity, DNA Cleavage, Alpha Amylase Inhibition Activity

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