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Vol. 10 No. 1.0 (2021)
Scholar : National School of Leadership

Research Articles

Synthesis, characterization and evaluation of anticancer activity of Ce3+ doped CuFe2O4 spinel nanoparticle synthesized by chemical coprecipitation method

Published 2021-06-30

  • T.V. Sheena
    • ,
  • B. Jyothish
    • ,
  • John Jacob

T.V. Sheena
Mar Ivanios College

B. Jyothish
Mar Ivanios College

John Jacob
Mar Ivanios College

Abstract

In the present study,CuCexFe2-xO4(x=0.00, 0.03 and 0.05) spinel ferrite nanoparticles were synthesized by chemical co-precipitation method. The structural, morphological, compositional and optical properties of the synthesized samples were estimated by powder X-Ray diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM), Energy Dispersive X-Ray Spectroscopy (EDX), Fourier Transform Infrared (FTIR) Spectroscopy and Uv-Vis-NIR Spectroscopy. The anti-cancer properties were analyzed at the in vitro level by MTT (3- [4, 5–dimethylthiazol-2-yl]-2, 5 diphenyl tetrazolium bromide) assay against human breast cancer MCF-7 cell line shows dose dependent cell viability in the concentration range of 6.25–100 µg/mL. In vitro cytotoxicity studies have shown that higher concentration (>25 µg/mL) of CuCexFe2-xO4 (x = 0.05) NPs shows reduced cell viability and induced cell membrane damage in cell line of L929 fibroblasts, but were found to be non-toxic at lower concentration suggesting their biocompatibility.

Keywords

Spinel Ferrite, Cytotoxicity, MCF-7 Cells, L929 Fibroblasts, Biocompatibility

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