Structural, Morphological and Cytotoxic Analysis of NixZ1-xFe2O4(x=0.00, 0.03, 0.07) Nanoparticles

Abstract

Nickel doped zinc ferrite compounds with the formula Ni_xZn_1-xFe₂O₄ (ZNFO) were prepared by using co-precipitation method.  The X-ray diffraction patterns confirm the synthesis of single crystalline Ni_xZn_1-xFe₂O₄ ferrite nanoparticles. The lattice parameter decreases whereas crystallite size increases with the increase in nickel ion concentration. The structure of nanoparticles was studied using X-ray diffraction pattern. The band gap energy for normal zinc ferrite is found to be 1.77.  Whereas the bandgap energy decreases to 1.03 eV  and 1.02 for Ni_x Zn_1-xFe₂O₄ with x = 0.03 and 0.07 respectively. FTIR will help to study the functional groups present in the nanoparticles, so this technique is used for qualitative analysis of materials. The microstrain decreases as nickel ion concentration increases. The obtained results revealed that Ni_xZn_{1- x}Fe₂O₄[x = 0.03] nanoparticles obtained by us in a model of actinomycetes exhibit lower cytotoxicity, which was confirmed in cytotoxic assay and with high LC₅₀ value. From safety point of view, a careful cytotoxicity analysis of ZNFO (0.03) nanoparticles with concentration up to 50µg/mL can be used for biomedical applications.

Keywords

Nanoparticles, W-H plots, Ferrites, XRD, FE-SEM

References

1. K. Vijaya Kumar, D. Paramesh, P. Venkat Reddy, Effect of aluminium doping on structural and magnetic properties of Ni-Zn Ferrite nanoparticles, 2015.
2. Reshma V. G and Mohanan P. V, Induction of cytotoxicity and oxidative stress of Dextran Coated Ferrite Nanoparticles (DFNPs) on A549 Cell lines, 2016.
3. Anitha, Usha, Jithin, Christy, Varughese, Characterization, Thermal effect on optical band gap energy and photoluminescence in wurtzite ZnO:Er Nanocrystallites, 2016, 145151.
4. I. Borhan, P. Samolia, Vasile HULEA, m. N. Palamaru, Effect of Al3+ substituted zinc ferrite on photocatalytic degradation of Orange I azo dye, 2014, 17-23.
5. Uday Kumar Sukumar, Bharat Bhushan, Poornima Dubey, Ishita Matai, Abhay Sachdev and Gopinath Packirisamy, Emerging applications of nanoparticles for lung cancer diagnosis and therapy, 2013.
6. M. Madhukara Naik, H. S. Bhojya Naik, G. Nagaraju, M. Vinuth, K. Vinu, S. K. Rashmi, Effect of aluminium doping on structural, optical, photocatalytic and antibacterial activity on nickel ferrite nanoparticles by sol-gel auto-combustion method, 2018.
7. Eman Z. Hegazy, Samla A. Kosa, Islam H. Abd Elmaksod, Jawaher T. Majamami, Preparation, characterization and photocatalytic evaluation of aluminium doped metal ferrites, 2019, 7318-7327.
8. S. S. Kumbhar, M. A. Mahadik, V. S. Mohite, K. Y. Rajpure, J. H. Kim, A. V. Moholkar, C. H. Bhosale, Structural, dielectric and magnetic properties of Ni substituted zinc ferrite, 2014, 114-120.
9. Parisa Maddahi,Nasser Shahtahmassebi, Ahmad Kompany, Mansour Mashreghi, S. Safaee, F. Roozban, Effect of doping on structural and optical properties of ZnO nanoparticles: Study of antibacterial properties, Material Science-Poland, 32(2):130-135, 2014.
10. Julio Isael Perez-Carreon, Jorge Melendez-Zajgla, In vitro and in vivo models for cancer research, Molecular Oncology Principles and Recent Advances,2012.
11. Simi Debnath, Ratan Das; Cobalt doping on Nickel ferrite nanocrystals enhances the micro-structural and magnetic properties shows a correlation between them, Journal of Alloys and Compounds, 2021, 852, 156884.
12. B. Jyothsh, John Jacob; Al-doped zinc ferrite nanoparticles: Preparation and evaluation of thermal, structural, morphological and anti-cancer properties, Journal of Alloys and Compounds, 2021, Vol 863, 158352
13. T.R Tatarchuk, Natalia D Paliychuk, M Bououdina, B Al-Najar, M Pacia, W Macyk, A Shyichuk; Effect of Cobalt substitution on Structural, elastic, magnetic and Optical properties of zinc ferrite nanopwder, J. Alloys and Compounds, 2018, Vol 731, 1256-1266.
14. Daniele R.Noguerira-Librelotto, Lais E Scheeren, Leticia B. Macedo, M.Pilar Vinardell, Clarice M.B Rolin; pH-Sensitive chitosan-tripolyphosphate nanoparticles increase doxorubicin-induced growth inhibition of cervical HeLa tumor cells by apoptosis and cell cycle modulation; Colloids and Surfaces B:Biointerfaces
15. Sneha Sigh, Sonal Singhal; Transition metal doped cobalt ferrite Nanoparticles: Efficient photo catalyst for photo degradation of textile dyes, Materials Today, 2019, 14, 453-460.
16. S.M Hosseini, I. Abdolhosseini Sarsari, P. Kameli, H. Salamati; Effect of Ag doping on Structural, Optical and photocatalytic properties of ZnO nanoparticles, Journal of Alloys and Compounds, 2015, 640, 408-415.
17. Rajinder Kumar, Ragini Raj Singh, P.B Barman; Cobalat doped zinc ferrite Nanoparticles- XRD analysis an insight, Inter. J. Scientific and Engineering Research, 2014, Vol 5, Issue 5, 2229-5518.
18. B Jansi Rani, G Ravi, R Yuvak Kumar, V Ganesh, S Ravichnadran, M Thambidurai, A.P Rajalekshmi, A Sakunthala; Pure and cobalt substituted zinc ferrite ceramics for Super capacity application, Applied Physics A, 2018, 124-511
19. Qing Lin, Jinpei Lin, Yun He, Ruijun Wang, Jianghui Dong; The structural and magnetic properties of Gadolinium doped CoFe2O4 nano ferrites, Journal of Nanomaterials, 2015, Article ID 294239, 6 pages
20. B. Jyothish, John Jacob; Effect of temperatures on structural on structural, morphological and bio -properties of zinc ferrite nanoparticles, IJPSR, 2020, 54, 6391-6401.
21. Kamel Shoueir, M. K. Ahmed, Sara A.Abdel Gaber, Maged El-Kemary; Microstructural features and in vitro lung cancer activity of thallium and selenite doped carbonated hydroxyapatite, Ceramics international; SO272-8842(19)33142-6.
22. B Jyothish, U.S Geethu, John Jacob, Influence of Ag1+ and Co2+ doping on structural, optical and anti-cancer properties of ZnFe2O4 nanoparticles synthesized by co-precipitation method, Materials Science and Engineering B, 276, 115544 (2022).