IN VITRO STUDY OF INHIBITORY EFFECT OF LEAVES OF AEGLE MARMELOS ON STRUVITE CRYSTAL URINARY STONES

Abstract

Many people suffers urinary stone problems. Urinary stones contain calcium phosphate, calcium oxalate, uric acid and magnesium ammonium phosphate.. Struvite commonly known as Ammonium Magnesium Phosphate Hexahydrate (AMPH) and Magnesium Hydrogen Phosphate.Struvite calculi, found in 15–20% of urinary calculi are mostly connected to urinary tract infections. They are present in women and in persons older than 50 years. Herbals presently available for the treatment of kidney stones are leaves of Aegle marmelos. With an increase in the concentration of methanol extract of leaves of Aegle marmelos. The formed crystals weight were gradually reduced . The ranges were 2.86 g to 0.43 g in struvite crystals, respectively. This research provides a multidisciplinary approach in characterizing urinary stone struvite crystals grown in vitro to help, formulate prevention or dissolution strategies in controlling calcium urinary stone growth. Therefore, the purpose of this research is to investigate the beneficial effects of leaves of Aegle marmelos at a different dose and single compound for the prevention of kidney stone formation. In the result of the study it was concluded that the test drug Aegle marmelos has shown inhibitory activity on struvite crystals growth.
Key Words: Aegle marmelos, Kidney stone, Struvite crystals