RAPID AMINATION OF METHOXY PYRIDINE WITH ALIPHATIC AMINES

Abstract

A n-BuLi triggered practical amination protocol of methoxy pyridine derivatives with aliphatic amines was developed. The reaction could finish in 30 min for primary amines and 10 min for secondary amines. The amination is further highlighted by its excellent reactivity and substrate scope.KEYWORDS: amination, methoxy pyridines, n-BuLi, transition-metal-free