CERIC (IV) AMMONIUM NITRATE CATAYSED HUNTZSCH SYNTHESIS ,CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF 1-4 DIHYDROPYRIDINE

Abstract

1,4-Dihydropyridine (1,4-DHP) is among the most beneficial scaffolds that have revolutionized pharmaceutical research with unprecedented biological properties. 1,4-dihydropyridines are generally synthesized by Huntzsch reaction which involve the condensation of aldehyde, betaketoester, and ammonia or ammonium acetate. A number of improved methods have been reported in the literature for this condensation which involves the use of microwave, ionic liquids, TMSI etc. This work involves the synthesis of Diethyl4-(phenyl)’2,6-dimethyl-1,4-Dihydropyridine-3,5-dicarboxylate by the condensation of ethyl acetoacetate, benzaldehyde and ammonium acetate in presence of an effective catalyst Ceric(IV) Ammonium Nitrate in methanol, characterization of the sample by TLC, column chromatography and NMR. The work involve also the antibacterial activity of 1, 4-dihydropyridine. Huntzsch 1, 4- dihydropyridines and their derivatives have gained great importance in the field of medicinal chemistry since they display a fascinating array of pharmacological properties. 1, 4-dihydropyridines are well known as calcium channel blockers and important classes of drugs for the treatment of several cardiovascular