A probe into the literature survey clearly reveals no work has been administered for the synthesis of pyrazinamide(TLC) using Teraphthaldehyde . therefore this study aimed to figure and produce highly effective medicinal hydrazide derivatives are synthesized from Schiff base route. The structure of the ligand THC and its complexes were carried various spectral studies. From these studies, i do know about the knowledge of chemistry and spectroscopy. The main objective of this study is to synthesis of pyrazineamide and teraphthaledehyde to determine the structure through the analytical (elemental and TLC) and spectral (IR, H1 NMR and C13 NMR) methods of characterization