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BIOPIONEERING WORK OF ANIMINATION OF SECONDARY ALCOHOL WITH A AMMONIEA

Abstract

we have presented a new and scalable procedure for the direct amination of cyanohydrins with the partnerofammoniaviatitanium-catalyzedcyano-borrowing reaction. an atom-efficient and very selective catalytic route for the direct synthesis of primary amines from secondary alcohols and ammonia without the need for protecting groups. The scope of the reaction includes cyclic and acyclic aliphatic substrates, as well as unsaturated and aryl-substituted alcohols

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