ELECTROPHILIC Α-AMINATION REACTION OF Β- KETOESTERS USING N-HYDROXYCARBAMATES: MERGING AEROBIC OXIDATION AND LEWIS ACID CATALYSIS

Abstract

The power of nitrosocarbonyl chemistry and demonstrate their potential as new viable electrophilic source of nitrogen in α- functionalization reaction.Nitroso carbonyls as an alternative to aryl nitroso compoundsprovidetheproductswithasynthetically easily manipulated N—carbonyl bond.we present the development of the first N-selective nitrosoaldol reaction utilizing nitrosoformate esters, generated in situ, astheelectrophilicsourceofnitrogen Asymmetric a-amination of carbonyl compounds is ofconsiderablesignificanceinorganicsynthesis.The chiral a-amino carbonyl products are versatile build- ing blocks, and they can be easily transformed into new valuable functional compounds, such as a-aminoacids,a-aminoaldehydes,andb-aminoalco- hols