A probe into the literature survey clearly reveals no work has been carried out for the synthesis of (E)-N’-(2,4-dichlorobenzylidene) nicotinohydrazide) using 2,4- dichlorobenzaldehyde and nicotine hydrazide. Aim and scope of the work is highly effective medicinal hydrazide derivatives have been synthesized from Schiff base route. The structure of the ligand (E)-N’-(2,4-dichlorobenzylidene) nicotinohydrazide) and its complexes were carried various spectral studies. From these studies, I know about the knowledge of organic chemistry and spectroscopy.In my present work, we have to synthesis (E)-N’-(2,4- dichlorobenzylidene) nicotinohydrazide) and establish the structure through the analytical (elemental and TLC) and spectral (IR, H1 NMR and C13 NMR) methods of characterization.