ADDITION –ELIMINATION PROCESS OF 2,4-DICHLOROQUINOLINE SYNTHESIS AND PHARMACOLOGICAL IMPORTANCE

Abstract

In terms of the diversity of quinolines, 2,4-dichloro compounds can play a role as key intermediates in synthesis of 2,4-disubstituted quinolines by possible stepwise substitution at C4 and C2 positions, where the chance for study of regioselectivity is more. This obvious significance prompted us to study the selectivity referred to 2,4-dichloroquinolines, in which one of the chlorine is selectively replaced under controlled temperature to yield new molecular structures with high pharmacological importance or with interesting properties.