Scholar: National School of Leadership

Research Articles

Vol. 10 No. 1.0 (2021): Scholar : National School of Leadership

SYNTHESES OF 4, 6-DIPHENYLPYRIMIDIN-2-ONE AND 4, 6 DIPHENYLPYRIMIDE-2-THIONE FROM BENZALACETOPHENONE (CHALCONE)

Submitted
November 27, 2022
Published
June 30, 2021

Abstract

Nitrogen containing heterocyclic compounds dihydropyrimidinone and its sulphur analogue, diphenylpyrimidine-2-thione, have been reported to possess many pharmacological properties such as anticancer, anti-HIV, antibacterial, antimalarial, antihypertensive, sedative, hypnotics, anticonvulsant, antithyroid and as antibiotics. 4, 6- diphenylpyrimidin-2-one and 4, 6-diphenylpyramidine-2-thione were synthesised by the reaction of benzalacetophenone (chalcone) with urea and thiourea respectively using ethanol as the solvent. Benzalacetophenone was synthesized by Claisen-Schmidt reaction by condensing acetophenone with benzaldehyde in the presence of an aqueous alkali. The structures of benzalacetophenone (chalcone), 4, 6-diphenylpyrimidin-2-one and 4, 6-diphenylpyrimidine-2-thione were confirmed by NMR (1H, 13C), FTIR & MASS spectral data

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