SYNTHESIS CHARACTERISATION AND ANTIBACTERIAL ACTIVITY STUDIES OF PICOLIOHYDRAZIDE(2-PYRIDINE CARBOXYLIC ACID HYDRAZIDE)

Abstract

Hydrazides derivatives are the type of organic compounds containing a nitrogen-nitrogen covalent bond with one of the substituents being an acyl group. Hydrazides and their derivatives have gained prominence because of their antibacterial,anti-inflammatory, anticancer, antiplatelet, antimalarial, analgesic and antioxidant activity. In addition to this they are also employed as potential inhibitors for controlling corrosion of many metals including mild steel (1).Hydrazide–hydrazones constitute a class of organic compounds, which attracts the attention of medicinal chemists due to the fact that they contain azomethine group (–NH–N=CH–) connected with carbonyl group, which is responsible for their different pharmaceutical applications and makes possible the synthesis of different heterocyclic scaffolds.